innate immunity §

Physical Barriers §

Type	Skin	Gut	Lungs	Eyes/Nose/Oral
Mechanical1	Flow of air	Flow of air / mucus	Flow of mucus by cilia	Tears / Nasal cilia
Chemical	Fatty acids, β-defensins, Lamellar bodies, Cathelicidin	Low pH & Enzymes (pepsin), α-defensins, Reg III, Cathelicidin	Pulmonary surfactant, α-defensins, Cathelicidin	Lysozyme, Histatines, β-defensins
Microbiological	Normal Microbiota	”	”	”

Early non-adaptive mechanisms §

Plasma protein and cellular systems contribute to non-adaptive immunity.

Plasma protein systems:

• complement system
• coagulation system and fibrinolytic system
• kinin system

Cellular systems:

• PMN
• mast cell
• endothelial cell
• platelet
• macrophage
• dendritic cell
• natural killer cell
• other innate lymphoid cells

These are mediators of inflammation. Molecules contributing to defence / inflammation include.

• Vasoactive amines: histamine, serotonin (granules)
• lysosomal proteins (granules)
• prostaglandins and leukotrienes
• PAF
• ROS
• NO
• cytokines
• interferons (type 1)

complement

Footnotes §

1. Epithelial cells are joined by tight junctions ↩