endoplasmic reticulum-associated protein degradation §

Comprises several general cellular pathways that involve the recognition and delivery of misfolded proteins to a retrotranslocation complex that unfolds and translocates the proteins across the ER membrane and into the cytosol. During the process the proteins are ubiquitinated and targeted by the UPS.

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Many viral pathogens co-opt these ERAD pathways to block assembly of MHC class I molecules as a way to evade recognition by CD8+ t-cell.