defective ribosomal products §

Translation of self or pathogen-derived mRNA in the cytoplasm generates properly folded proteins but also a significant quantity - up to 30% - of peptides and proteins that are known as DRiPs. These include:

• Peptides translated from introns in improperly spliced mRNAs
• Translations of frameshifts
• Improperly folded proteins Which are tagged by ubiquitin for rapid degradation by the proteasome.